It is noteworthy that PGL has been considered subject to abuse when formulated with various substances. Several samples, which contained numerous substances and manufactured by unauthorized factories for non-medical purposes, were seized in some countries. Common compounds detected alongside PGL included cannabis products, opioids (e.g., morphine, hydromorphone and codeine), semi-synthetic analogues (e.g., hydrocodone), and over-the-counter medications (e.g., paracetamol and naproxen) (Teker et al., 2024).
6 Analysis by LC-MS/MS
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- Recent studies have well-documented PGL misuse, particularly among polydrug users and opioid-dependent individuals (Kriikku and Ojanperä, 2021).
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- In this study, 40 seized samples (powder and capsule samples) were analysed using UPLC instrumentation.
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In connection to this, health risks linked to the abuse of PGL with other compounds are considered serious. As PGL is known to depress the Central Nervous System (CNS), its use with other CNS depressants significantly elevates the danger of severe toxicity and mortality. When combined with opioids, cannabis products, and other depressing agents, PGL loses its therapeutic efficacy and considerably enhances the risk of severe adverse effects or potentially fatal outcomes (Elliott et al., 2017). Hence, developing selective analytical methods for PGL in the presence of various additives is highly desirable to be applied at forensic, toxicological, and pharmaceutical laboratories. Furthermore, the study aims to identify PGL contents and purity levels along with buy lyrica uk potential adulteration.